Design optimisation and characterisation of films for delivering poorly soluble hydrophobic drugs to wounds

Despiteadvancements in wound management, chronic wounds still fail to heal anappropriate time and manner. Hydrophobic drugs of interest the pharmaceuticalindustry exist that are suggested reduce inflammation aid woundhealing process; however, delivering these poses a challenge both interms ease formulation processing drug release characteristics whenapplied vivo. Naturally occurring, biocompatible, bioactive excipients,such as hydroxyethylcellulose (HEC) andcitric acid (CA) hydrophilic widely used management anddelivery soluble drugs. However, hydrophobic not compatible inthis environment without addition molecules, such β-cyclodextrin(βCD), which acts carrier allows delivery. This study investigatedthe use CA development achieve crosslinking HEC βCDto allow incorporation poorly model The prepared filmshave been characterized for their functional physico-chemical properties relevantfor healing applications.